Temperature and electrophysiology?

tomte tehgabriel at web.de
Mon Dec 27 11:01:23 EST 2004


Hi!

I had a debate with a collegue of mine, wether an increase of
temperature from 34.5°C to 36°C may lead to significantly different
effects in whole-cell patch-clamp recordings (I refer to experiments
on rat brain slices).
Of course there's no question that one may obtain different results
when experiments were done at 10°C or 20°C. But what's the situation
in the special case i mentioned at the beginning (sligthly
temp.difference in a regime close to body temperature).
What's your opinion/experience?

Any comment would be appreciated
Cheers,
Thomas

p.s.:
I would be very grateful for references



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