An electrophysiology quesiton
xli6 at gmu.edu
Wed Feb 11 12:50:26 EST 2004
Thank you so much for your great explanation. It really helped me a lot.
I have another question related with voltage clamp. This question is
"An interesting side issue worth mentioning here is that a voltage clamp
applied to one end of a cable is mathematically equivalent to a short
circuit at that end. The use of a voltage clamp will thus fundamentally
alter the electronic structure of a neuron..." (Foundations of Cellular
Neurophysiology by Johnston and Wu, 1995, page 78)
Could you explain why a voltage clamp on a neuron is adding a short
circuit to the neuron? Since voltage clamp changes the electronic
structure of a neuron, all the data obtained is actually from a changed
neuron. Maybe there is a need to reinterpret the published voltage clamp
data if the original authors were not aware of this issue.
Thank you so much for your help.
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