An electrophysiology quesiton

k p Collins kpaulc at [----------]earthlink.net
Wed Feb 11 18:52:50 EST 2004


Hi Xiaoshen,

I've never heard of it elsewhere, but, if I
understand correctly, it's =part= of what
I've been discussing.

Neurons do 3-D energydynamics.

To see what neurons do, one has to see
the 3-D energydynamics.

What I've been discussing are ways to
approach doing this - how to enhance
experimental designs so that they in-
creasingly see the 3-D energydynamics.

I do it by reducing everything to the
Fundamentals - 'just' the energy, itself,
how the directionality of its motion is
determined, and how that determined
energy-motion-directionality tunes the
activation of the genetic material, and,
hence, protein [and enzyme] synthesis,
all in a way that feeds-back [feeds-
forward] into the the determination of
the directionality of energy's motion.

Folks don't like it, because it's 'un-
familiar', but this stuff is what's =nec-
essary= to do.

I'm not 'familiar' with it, but I hope that,
if there's a methodology of a "Dynamic
clamp", it's designed to look-into the
stuff I've outlined above.

A "clamp" inherently interferes with the
3-D energydynamics, though, so, if
such a technique is to be viable, it must
be tunable with respect to various con-
stituents of the 3-D energydynamics, or
there must be a number of "Dynamic
clamps" that, function 'together' to yield
an overall-'picture' of the 3-D energy-
dynamics.

I hope someone else will have something
to offer with respect to this last query of
yours.

Cheers, Xiaoshen, ken, [k. p. collins]

"Xiaoshen Li" <xli6 at gmu.edu> wrote in message
news:c0e6bf$j7d at portal.gmu.edu...
> Dear Everybody:
>
> My original post has become centered around what is voltage clamp and
> what is current clamp and what is the purpose of each technique. Voltage
> clamp and current clamp have been the only two choices for an
> electrophysiologist. However recently I have heard that there is another
> new clamping technique now. It is called "Dynamic clamp". It is said
> that this techniqure provides some new information which V-clamp or
> I-clamp cannot.
> Could anybody explain what dynamic clamp is and compare it with V-clamp
> and I-clamp?
>
> Thank you very much.
>
> Sincerely,
> Xiaoshen
>
> Xiaoshen Li wrote:
> > Hi,
> > I have an electrophysiology question. I read somewhere "somatic EPSCs
> > under passive voltage clamp conditions...". What is "passive voltage
> > clamp"? I am always confused EPSC and EPSP. In voltage clamp condition,
> > are we measuring EPSCs?
> >
> > Thank  you very much for your help.
> >
> > Best Regards,
> > Xiaoshen
> >
>





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