An electrophysiology quesiton

k p Collins kpaulc at [----------]earthlink.net
Wed Feb 11 19:00:25 EST 2004


Hi Xiaoshen,

"Xiaoshen Li" <xli6 at gmu.edu> wrote in message
news:c0ebjc$ktr at portal.gmu.edu...
> Matt,
>
> Thank you so much for your great explanation. It really helped me a lot.
> I have another question related with voltage clamp. This question is
> following:
>
> "An interesting side issue worth mentioning here is that a voltage clamp
> applied to one end of a cable is mathematically equivalent to a short
> circuit at that end. The use of a voltage clamp will thus fundamentally
> alter the electronic structure of a neuron..." (Foundations of Cellular
> Neurophysiology by Johnston and Wu, 1995, page 78)
>
> Could you explain why a voltage clamp on a neuron is adding a short
> circuit to the neuron? Since voltage clamp changes the electronic
> structure of a neuron, all the data obtained is actually from a changed
> neuron. Maybe there is a need to reinterpret the published voltage clamp
> data if the original authors were not aware of this issue.
>
> Thank you so much for your help.
>
>
> Sincerely,
> Xiaoshen

=EXACTLY=.

Cheers, Xiaoshen, ken [k. p. collins]





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