DC lesion?

Klenow bakedbeans at spam.not
Sat Feb 14 01:53:28 EST 2004


The reason I'm asking about a lesion is that they claim there is a
long-lasting (maybe permanent) increase in seizure threshold akin to
kindling's permanent lowering of seizure threshold.


"k p Collins" <kpaulc@[----------]earthlink.net> wrote in message
news:Z4jXb.4907$hm4.4138 at newsread3.news.atl.earthlink.net...
> "Klenow" <bakedbeans at spam.not> wrote in message
> news:PxiXb.9020$%h1.7659 at fe24.usenetserver.com...
> >
> > I've recently read a paper looking at the effects of 15 minutes of
direct
> > current stimulation (5-15 uA) through a chronic indwelling electrode on
> > kindled seizure thresholds in rats.  Can this type of stimulation cause
an
> > electrolytic lesion at the electrode tip even with such low current?
I've
> > been looking through brain stimulation books and can't find an answer.
> >
> > --
> > -----
>
> I don't know about a resultant lesion,
> but the neural architecture is just like
> any other machine. It's 'engineered'
> to function as it's engineered to func-
> tion, and 15 'minutes' of DC is con-
> trary to everything that's 'engineered'-
> in-there.
>
> Stick a screw driver in the works of
> a grandfather clock, or in the spokes
> of a bycycle that's riding by - same-old,
> same-old.
>
> In the neural architecture, what happens
> is that the DC desynchronizes the 'norm-
> ally exquisitely-synchronized ["Type II]
> neural dynamics. The result is exactly-
> analogous to 'stripping-the-gears' of
> any machine's mechanism.
>
> ken [k. p. collins]
>
>






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