On Sun, 15 Feb 2004 14:32:36 GMT, "Glen M. Sizemore"
<gmsizemore2 at yahoo.com> wrote:
} I'm sure it is. These drugs have been investigated for years because of the
} abuse aspect, and I'm sure the affinities have been worked out. My guess is
} that the people that invent compounds like this do binding studies
} immediately. I have a paper coming out soon and one of the authors is a
} chemist who makes cocaine- and methyphenidate-like drugs (he has made
} dozens), and the relative binding affinities for the various monoamine
} transporters are the first thing examined.
Drop a note when it's out. I try to keep up on DA/MAO work.
I did some work on the effects of a DAT blocker and MAOI in tobacco
with respect to prevention of parkinsonism (blocking the MPTP to MPP+
reaction). They told me the effects, and I had to come up with and
test for EEG changes. By the time I could give them the results to
"justify" doing the chemistry, they'd already isolated and tested the
compound. Transdiscipline science is lots of fun, but the parallel
projects don't always run the same speed.