"r norman" <rsn_ at _comcast.net> wrote in message
news:ogr6309a583nll65nr1nsva79kbujks2no at 4ax.com...
> On Wed, 18 Feb 2004 13:07:11 +0100, "ZaLTaR" <ZaLTaR666 at Hotmail.com>
>> >Is it possible to use a Re-Uptake compound in combination with serotonin
> >refull the serotonin levels in the brain after
> >the release of this substance ?
>> Your question is far too general to really answer. Yes, serotonin
> reuptake is an important mechanism to re-establish presynaptic
> serotonin stores after release. The presynaptic terminal also
> synthesizes serotonin and that also refills the system.
>> The real question is why you would suggest alterning the natural
> process. If things are working normally, then there is no need to
> change anything. If things are going wrong, then you have to look at
> just what the problem is before trying to fix it. The problem could
> be failure to synthesize it, problem to release it, problem to respond
> to it postsynaptically, problem to recycle it. Usually, a "deficiency"
> in serotonin response is treated with a reuptake inhibitor, not a
> reuptake stimulator. By inhibiting reuptake, you make the serotonin
> that is released stay longer in the synaptic gap and therefore exert
> more of an effect.