Some amphetamine affinities

BilZ0r BilZ0r at TAKETHISOUThotmail.com
Thu Feb 19 16:38:18 EST 2004


Reuptake transporter = Reuptake carrier, and Although I've never heard it 
before, presumabley they are all the same as the reuptake receptor.

What I am after is a single experiment that quantifies, either in terms 
of EC50s, or Ki/d/m (whatever) the affinity for those various 
amphetamines for the 5-HT reuptake transporter/carrier/receptor and the 
dopamine transporter/carrier/receptor. The reason why Im after the 
affinities in one paper, is that I find wildely varying affinities from 
one paper to the next.

David Longley <David at longley.demon.co.uk> wrote in news:99WQuKIuR
$MAFwOg at longley.demon.co.uk:

> I once worked with DSP-4 (N-2-chloroethyl-N-ethyl-2-bromobenzylamine 
> hydrochloride) as an alternative to 6-OHDA) whilst looking at forebrain 
> NE' (and other monomaines') role in various aspects of learning. It 
> looks like the term "transporter" is being used here as a synonym for 
> (presynaptic) "reuptake receptor". Is that the case? I used to use DMI, 
> 5-7 DHT, but not MDMA in control groups. I thought these ligands were 
> somewhat dirty and bound to lots of receptors - is this what you're 
> interested in, ie their relative affinities (sorry if this has all been 
> said earlier).
> 
> This is really a trivial question for my benefit, as I expect matters 
> have moved on considerably since my day (although I do try to keep up 
> with some of it).




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