what is down-regulation?

Dr. Andrew B. Chung, MD/PhD andrew at heartmdphd.com
Thu Jan 29 10:02:57 EST 2004


jjones at bone.net wrote:

> what does down regulation mean in the context of the glucocorticoid
> receptors in the hypothalamic pituitary axis in response to low cotisol
> levels (like in the event of PTSD)?

The expression of the gene for the glucocorticoid receptor may be dialed
down.

This means less mRNA for this gene which means less receptors.


> thanks.

You are welcome.

Humbly,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/





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