Interneurons and synaptic symmetry
m.kirkcaldie at removethis.unsw.edu.au
Mon May 3 04:03:17 EST 2004
In article <Xns94DED361E7D34BilZ0rhotmailcom at 18.104.22.168>,
BilZ0r <BilZ0r at TAKETHISOUThotmail.com> wrote:
> So bassically, there are more psd-95-esque proteins associated with
> excititory receptors?
I wouldn't hazard a guess as to what the PSD is composed of specifically
- for instance, the LTP/D related cycling of AMPA receptors to and from
the synaptic surface may involve structures buried in that PSD as well
(and all the clathrins, etc, involved in the cycling itself). I know
some people have fractionated the synapses out and I'm sure someone has
done a Western or a 2D gel on them, there must be references out there.
> In one of the papers, it says that some of the
> synapses in question are assymetric, but then contain dense-core
> vesicles, which under my understanding ment monoamine. What is the likely
> explanation there? That we have co-release, or that certain monoaminergic
> postsynaptic densities can be rather large?
Well of course it depends on the one synapse, one transmitter dogma - if
the vesicles are monoamine-containing then I would guess that adrenergic
or dopaminergic synapses are also asymmetric - after all, if we're going
to lump them into two groups then the minor transmitters must be in one
or the other! I guess co-release is an option which must be entertained
but I have no idea if there is any evidence for it.
Of course, the associations made between EM structures and biochemistry
may not be hard and fast, either; not an expert by any stretch of the
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