Testosterone, DHEA, Caffeinated Beverages and Blood Pressure in Adolescents

James Michael Howard jmhoward at arkansas.net
Thu May 6 13:35:53 EST 2004

Testosterone, DHEA, and "The Association of Caffeinated Beverages With Blood
Pressure in Adolescents" Archives of Pediatric and Adolescent Medicine 2004;
158: 473-477, Savoca, et al.,

"Conclusions  For adolescents, especially African American adolescents, caffeine
intake may increase blood pressure and thereby increase the risk of
hypertension. Alternatively, caffeinated drink consumption may be a marker for
dietary and lifestyle practices that together influence blood pressure.
Additional research is needed owing to rising rates of adolescent hypertension
and soft drink consumption."
Copyright 2004, James Michael Howard, Fayetteville, Arkansas, U.S.A.

I suggest the findings of Savoca, et al., may be explained by increased
testosterone.  Caffeine increases testosterone (Eur J Endocrinol. 2003
Aug;149(2):145-52).  Because testosterone inhibits steroid sulfatase,
testosterone may reduce the conversion of DHEAsulfate to DHEA, so testosterone
increases DHEAS ( Steroid Biochem Mol Biol. 2000 Jul-Aug;73(5):251-6).  High
levels of DHEAS in boys are connected to high blood pressure (Hypertension. 1986
Male and female African Americans produce more testosterone than whites.  I
suggest caffeine consumption increases testosterone levels which reduce
conversion of DHEAS to DHEA and increase blood pressure.  I suggest this may
explain the findings of Savoca, et al.,
James Michael Howard

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