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Sun Apr 10 20:48:08 EST 2005

"How does a large population of neurons in the brain work?  How can 
synchronized firing be achieved?  What factors regulate how many and 
which neurons will fire under different conditions?  These questions 
form the central theme of this book.   Using a combined experimental-
theoretical aproach that is new to neuroscience, the authors present 
important new techniques for the physiological reconstruction of a 
large biological neuronal network.  They begin by discussing 
experimental studies of the CA3 hippocampal region in vitro, focusing 
on single-cell and synaptic electrophysiology, particularly the effects 
one single neuron is able to exert on its connected followers.  This 
is followed by a description of a computer meodel of the system, first 
for individual cells, and then for the entire detailed network.  The 
model behavior is compared with experiments under a variety of 
conditions.  The results shed significant light on the mechanisms of 
epilepsy, EEG, and biological oscillations and provide an excellent 
"test case" for theories of neural networks.
  "Researchers in neurophysiology and physiological psychology, 
physicians concerned with epilepsy and related disorders, and students 
and researchers in computational neuroscience will find this book an 
involuable resource."

W. Douglas Knowles, Ph.D.          E-mail: knowled at ccsmtp.ccf.org
Dept. Neurosciences                          voice: (216)444-3870
Cleveland Clinic Foundation                  FAX:   (216)444-7927
9500 Euclid Avenue, Cleveland, OH 44195 USA                      

"Data is not information is not knowledge is not wisdom."

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