> Hello, can anybody give me a source of the DNA Promotorsequence
> of microtubule-associated protein tau in rat or human. Up to now
> I only got the cDNA sequence, but I urgently need the Promotorsequence.
[lifted from MEDLINE]
Authors
Andreadis A
Brown WM
Kosik KS
Institution
Department of Neurology (Neuroscience), Harvard Medical School, Boston,
Massachusetts.
Title
Structure and novel exons of the human tau gene.
Source
Biochemistry. 31(43):10626-33, 1992 Nov 3.
Abstract
The microtubule-binding protein tau is important in establishing and
maintaining neuronal morphology and is a major component of the
neurofibrillary tangles (NFTs) characteristic of Alzheimer's brain. The
neuron-specific tau transcript undergoes complex alternative splicing. The
human tau gene has been cloned and mapped. The restriction analysis and
partial sequencing of the gene shows that it contains (1) four
alternatively spliced exons previously described in rodent and bovine but
not in human tau cDNAs and (2) two CpG islands, one associated with the
promoter region, the other with exon 9. Examination of human tau mRNA
indicates that the human cerebrocortical splicing pattern differs from
that previously reported for the murine and bovine tau mRNAs, despite
conserved exon organization in all three genes.
--
Steve Matheson Program in Neuroscience University of Arizona
sfm at neurobio.arizona.edu
