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Sun Apr 10 21:08:19 EST 2005


end-plate by high concentrations of acetylcholine. Journal of Physiology.
 395:131-59, 1988:

At concentrations higher than 200 microM-ACh, po (open probability - MJ)
declined as a result of open-channel block by free ACh itself. 3. At
positive membrane potentials (+100 mV) there was little channel block by
ACh; po reached a maximum value of 0.41 at 500 microM-ACh, with
half-maximum activation at 50 microM and Hill slope of 1.2 at this point.




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