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Sun Apr 10 21:08:19 EST 2005


suxamethonium (succinyldicholine) as an agonist and channel blocker at
the nicotinic receptor of frog muscle. Journal of Physiology. 
428:155-74, 1990:

Suxamethonium (Sux)  was a more potent blocker of the open ion channel
than ACh  (equilibrium constant about 200 microM); this limited the
maximum open probability to about 0.36 (at 12 degrees C and -120 mV).
Individual  channel blockages lasted about 65 microseconds on average.
They appeared  to get longer at high agonist concentration; however, a
simulation method  was used to show that this effect could be accounted
for by the fact that  at higher concentrations there are more openings
that are too brief to be  detected. Over the concentration range tested
the effects were described  by a simple open channel block mechanism. 4.
No component of brief shut  times could be detected other than those
resulting from channel blockages.  However, the results suggest that
multiple channel openings (the  nachschlag phenomenon) should be rare, so
this is not inconsistent with  previous results with other agonists.




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