above mentioned properties(but,curiously,baclofen,which mimics Gamma-OH on many
points,is NOT a sociabiliser,though it can elevate mood and potently stimulate
sexuality in man while depressing sexuality in the mouse!
Here are some properties of Gamma-OH:
a.It is a very fast acting anti-depressant and will work in the most severe cases of
depression where imipraminomimetics will have no action.
Depression disappears to be replaced by an exhilarating feeling of JOY and HAPPINESS
of being ALIVE,associated with a desire of communication with other human beings.
Suddenly,suicidal ideation seems grotesque and you wonder how come you were suffering
so much for nothing! Life is seen,again,as BEAUTIFUL and worth living.Foregone hopes
and dreams come back into your existence making yourself again full of enthousiasm and
active..Stress is completely suppressed.This is why,for instance,my late
friend,Dr.Henri Laborit,used to take a Gamma-OH bottle just before making
He would then radiate to the audience with joy,enthusiasm,and happiness!
Henri Laborit is,maybe,the scientist who understood the best the human psyche
and,especially,human stereotypes and intra-specific aggressivity.
He worked all his life to combat those stereotypes and aggressive behaviours which
sterilise the "adult" human mind.
His recent death,this year,is a tragedy for Science.
b.It is a powerful anxiolytic and very useful against panic attacks which are replaced
by a state of happy and tranquil well-being.
c.It can suppress suicidal ideation within less than an hour.
d.It brings back old repressed memories and induces a very positive state of
crying.After crying under Gamma-OH you feel relieved.
e.It enhances recall of dreams which are remembered more vividly,with
f.It acts,a bit,like an electronic "Diode" on consciousness as,under Gamma-OH,we
are,normally,sensitive only to positive ideas and feelings while psychotoxic ideas or
emotions are,simply,automatically discarded.
g.It depresses aggression.Suddenly you may wish to communicate with the persons you
would,normally,consider as enemies...
This is a very important property which should be used in politics,in the same way
Kava was used,in the Pacific,so as to induce a tranquil state of mind for discussion.
The same holds true for scientists...
h.And,of course,as its name implies,it promotes SOCIAL INTERACTION and the PLEASURE
associated with social interaction.
i.It enhances love feelings in "lovers",contrary to many imipraminomimetics whick
block these subjective emotions and,thus,induce an emotional DEFICIT.
A substantial number of the imipraminomimetics are,in fact,thymoanesthesisers and not
authentic thymoanaleptics:they "suppress" depression by inducing a deficit:blunting of
affect,that is an anaesthesia of emotions.
So,thymoanesthesisers,cannot be classified as authentic anti-depressants but only as
Why Gamma-OH is so efficient in depression?
Because depression can be defined as a DEFICIT OF PLEASURE,due to INHIBITION OF SOCIAL
Some cultures are more depressogenic than others,in this respect.For
example,protestant cultures generate more psychopathologies than other cultures
because of the extreme repression of emotions.They are,thus,psychotoxic and
By stimulating the desire to INTERACT WITH OTHERS,then depression is AUTOMATICALLY
SWITCHED OFF,under Gamma-OH!
The Psychopharmacology of Gamma-OH is,still,largely unknown but we should focus our
attention,I think,to the Psychopharmacology of what is called the "MATERNAL INSTINCT"
in order to unravel the remarkable properties of this old but unknown molecule,as
SOCIABILITY SEEMS A MANIFESTATION OF MATERNAL BEHAVIOURS but expressed differently in
The development of Sociabilisers will,in my opinion,lead to a COMPLETE REVOLUTION in
the therapy of many psychopathologies including human intra-specific
But why did we wait until now to discover the remarkable properties of a molecule
invented 33 years ago?
One reason is because Gamma-OH is a short acting medicine:its effects subside within 1
hour and a half to 2 hours and repeated doses during the day should be used in order
to obtain an anti-depressant response.
Another reason is that the imipramnomimetic dogma sterilised research and,as all
dogma,completely blocked the research of authentic thymoanaleptics.
Moreover and worse:due to the chronic lack of enthusiasm of most scientists in the
fields of psychiatry and psychopharmacology and also due to the absence of serious
research on human beings(isolated people,like Shulgin,still do introspective
research),it took a great deal of time for this researcher to discover,at last,the
concept of thymoanesthesy(thymoanesthesia)and to understand that research in
depression,for instance,was going nowhere because of a constant confusion concerning
the logical nature of
what authentic anti-depressants should be like.
Claude (Bângkoc and Tôkiô).