[Neuroscience] Pharmacological induced "spontaneous" activity in vitro.

tehgabriel at web.de tehgabriel at web.de
Mon Apr 3 06:45:41 EST 2006


I have a question concerning sources of spontaneous activity in brain
Can solely application of GABA_A antagonists (e.g. bicuculline)
initiate spiking activity in cortical neurons (in vitro!)?
I know there is plenty of literature concerning effects of bucuculline
in the hippocampus. But I am interested how bicuculline might affect
network activity in structures that usually show no spontaneous spike
activity (e.g. prefrontal cortex).
Any ideas? Any references?

Thanks for your comments!


More information about the Neur-sci mailing list