[Neuroscience] Re: Maltoma

Paul T. Holland pholland at bellatlantic.net
Thu May 25 19:33:32 EST 2006


MALTomas stand for mucosal associated lymphoid tissue. These are the
extra-nodal equivalent of monocytoid (marginal zone) B-cell lymphomas
occurring in lymphoid organs such as the lymph node. These lymphomas
arise in numerous extranodal sites such as the stomach, salivary gland
and thyroid, most of which lack native lymphoid tissue but acquire MALT
in close association with chronic inflammation or autoimmune processes.
MALT lymphomas appear to have similar clinical, pathological and
molecular features regardless of organs of origin.

this is often seen in helicobacter pylori-related tumors

once held:

"MALT lymphocyte traffic does not involve nerve and low grade MALT
lymphoma does not disseminate to CNS or peripheral nerve, rather to
other MALT sites such as lung, stomach, eye, liver. low grade B cell
lymphoma of peripheral nerve is rare but recognised (Am J Surg Path
14:881  1990) in its own right.  Primary low grade neural lymphoma often
shows plasmacytic differentiation and could look MALToma-like."

but now found can also involve the cns fibers; this is so specialized,
that you might want to start with:

http://www.lymphomation.org/type-malt.htm
http://www.lymphomainfo.net/lymphoma/glossary.html

hth
paul

M wrote:

> Can someone please tell me how Maltoma can affect the CNS?



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