[Neuroscience] Re: Long-term potentiation and depression

Bill via neur-sci%40net.bio.net (by connelly.bill from gmail.com)
Sat Jun 14 18:05:09 EST 2008


On Jun 15, 12:35 am, usene... from out-of-phase.de (Christian Wilms) wrote:
> Entertained by my own EIMC <de... from mindyaown.biz> wrote:
>
> > Yes, when "hours" is meant to imply "a lifetime" it takes just a second
> > for someone like me to misinterpret the minutiae of this meaning.
>
> I would be willing to bet against "a lifetime"  when it comes to classic
> LTP/LTD. I think long-term "storage" will prove to be mediated by a
> different mechanism.
>
> Best, Chris

Well there is LTP and there is LTP like mechanisms. Nothing in the
brain is done by LTP (100Hz for 1 sec 3 times). However strong
depolarisation leading to NMDA receptor dependent enhancement of
synaptic strength, I would be willing to bet that memory formation,
and maintainance is deeply dependent on this kind of mechanisms. (Re:
How long does LTP last, at least a year in an Adult Rat Perforant path-
DG (Abraham WC. How long will long-term potentiation last? Philos
Trans R Soc Lond B Biol Sci. 2003 358(1432):735-44)


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