[Neuroscience] Re: Differential Attenutation of EPSPs in Voltage Clamp vs Current Clamp

Bill.Connelly via neur-sci%40net.bio.net (by connelly.bill from gmail.com)
Fri Aug 7 18:22:30 EST 2009


Oh, so when the current is generated far away, the voltage clamp kind
of acts like a lot of open channels, i.e that end of the cable appears
to have low resistance?

On Aug 8, 1:33 am, r norman <r_s_nor... from comcast.net> wrote:

> With voltage clamp, there is essentially a "short circuit" across the
> cable at the point of the clamp.  This causes a rather drastic
> alteration in the pattern of current flow pattern when the clamp is
> close to the synapse.  However when the clamp is farther down the
> cable, the current flow near the synapse is virtually unchanged.  As a
> result, when the clamp is near the synapse it "steals" pretty much all
> the current, far more than would pass that way unclamped.  When the
> clamp is far from the synapse, it only gets what current would
> normally end up passing that far anyway.  Hence an apparent "faster
> decay with distance" in voltage clamp than unclamped.



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