[Neuroscience] May depolarization induced hyperpolarization possible?

[Dhruba Pathak]

Hi all,
Instantly application of drug A increase frequency of spontaneous
activity with significant level of depolarization. The substance A was
applied for 10 minutes. The membrane potential starts to decline by
itself (no any interference was done from application of substance to
get this observation). what do you think, is it the effects of
depolarization induced hyper polarization or some secondary reason for
declining the membrane potential? Moreover, the cell stops firing in
this hyperpolarization phase gradually. Lets suppose A be any voltage
gate K-channel blocker. Finally cell restores sponatenous activity
under normal saline.

Thanking in advance.

Sincerely,
Dhruba Pathak