Graham Clark graham.clark at LSHTM.AC.UK
Thu Dec 11 04:52:11 EST 1997

Hi Andre-Denis,

I'm one of the authors responsible for some of the papers you refer to:


Clark, C.G., Roger, A.J. 1995 Proc. Natl. Acad. Sci. USA 92, 6518-6521


Bui, E.T., Bradley, P.J., Johnson, P.J. 1996 Proc. Natl. Acad. Sci. USA 	=

93, 9651-9656

Horner, D.S., Hirt, R.P., Kilvington, S., Lloyd, D., Embley, T.M. 1996 =

Proc. R. Soc. Lond. B Biol. Sci. 263, 1053-1059.

Germot, A., Philippe, H., Le Guyader, H. 1996 Proc. Natl. Acad. Sci. USA
93, 14614-14617

Roger, A.J., Clark, C.G., Doolittle, W.F. 1996 Proc. Natl. Acad. Sci. USA =

93, 14618-14622 =


Germot, A., Philippe, H., Le Guyader, H. 1997 Mol. Biochem. 	Parasitol. =

87, 159-168

Hirt, R.P., Healy, B., Vossbrinck, C.R., Canning, E.U., Embley, T.M. 	=

1997 Curr. Biol. (in press)


Roger, A.J., Svard, S.G., Tovar, J., Clark, C.G., Smith, M.W., Gillin, =

F.D., Sogin, M.L. 1998 Proc. Natl. Acad. Sci. USA (In Press)

The common theme in all the papers is that the organisms encode chaperonins
(cpn60, cpn10 and/or hsp70) that have clear and specific relatedness to
the mitochondrial isoforms of these proteins. The most parsimonious =

explanation for this is that they are descended from ancestors that had
mitochondria or harboured the symbiont that gave rise to mitochondria.


C. Graham Clark, Ph.D.
Department of Infectious and Tropical Diseases,
London School of Hygiene and Tropical Medicine,
Keppel Street, London WC1E 7HT, England, G.B.
Tel: ++44-171-927-2351
FAX: ++44-171-636-8739
e-mail: g.clark at

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