Bioresearch Online Newsletter

Bioresearch Online newsletter at VERTICAL.NET
Wed Aug 4 23:45:43 EST 1999

Bioresearch Online Newsletter
Volume 2   Issue 41
Wednesday, August 04, 1999

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******** Bioresearch Online’s Weekly Selection: ********

An Introduction to Genetic Engineering by Desmond Nicholl
Some twenty years have passed since the first recombinant DNA molecules were
constructed at Stanford University. Genetic engineering is now a reality.
Our Price: $19.95!
To read more and purchase this book, visit:

***** FEATURED ARTICLES selected by Laura DeFrancesco *****

1) SNP Detection by Enzymatic Means
2) Light Microscopy Diffraction Limit Overcome
3) Bioresearch Online Bolsters Online Commerce Through Acquisition


1) SNP Detection by Enzymatic Means
So you want to get into SNP detection, but you’re not quite ready to turn in
your gel stand for DNA chips and readers. Well, you don’t have to. This last
installment on SNPs looks at several enzymatic approaches to SNP detection,
which, like the solid phase systems described in previous articles, are both
high throughput and sensitive. And the good news is that all three methods
require little more than the basic gel apparatus.

2) Light Microscopy Diffraction Limit Overcome
Scientists at the Max Planck Institute for Biophysical Chemistry have overcome
the traditional resolution limitation of light microscopy (the wave nature of
light). As reported in the July 15 issue of Optics Letters, Thomas Klar and
Stefan Hell used a process known as stimulated-emission depletion (STED) to
sculpt a fluorescence signal, thereby increasing resolution.

3) Bioresearch Online Bolsters Online Commerce Through Acquisition
And now for a little self-promotion. Bioresearch Online’s parent company,
VerticalNet Inc. has acquired, one of the Internet's leading trading
communities for used and excess scientific laboratory equipment. The resources
and technology developed by LabX will soon be added to the three communities in
the VerticalNet science group: Laboratory Network, Bioresearch Online, and Drug
Discovery Online.

******** EDITOR'S CHOICE PRODUCTS ********

1) Integrated Co-Reporter Assay
2) Stereomicroscope
3) Magnetic Particle Processor


1) Integrated Co-Reporter Assay
Promega's Dual-Luciferase Reporter Assay System provides an integrated co-
reporter assay by combining the firefly luciferase assay with an assay for a
second luciferase, Renilla luciferase. In this system, the activities of the
firefly and Renilla luciferases are measured sequentially from a single sample,
requiring 30 seconds to complete in low throughput and approximately four
seconds in high throughput applications.

2) Stereomicroscope
Providing standard magnification range from 6.7 to 80x, Leica's MZ9.5
stereomicroscope has 9.5:1 zoom for biological and life science applications.
The lenses on this instrument were developed by computer-controlled design
systems, and the modular design of the microscope permits the user to add
accessories and customize it for specific applications.

3) Magnetic Particle Processor
Labsystem's KingFisher Magnetic Particle Processor is the first machine of its
kind to isolate pure single stranded DNA. The 11-step procedure takes place in
a single place and is performed by pushing a button. During these steps, beads
are collected, washed, incubated and mixed with the sample, the biotinylated
dsDNA. At the end, magnetic beads carrying pure ssDNA are released into the
last well, and the free complementary DNA strand can be found.

******** Drug Discovery Technology '99 ********

The World's Drug Discovery Meeting Place, August 16-19, 1999 in Boston, MA,
followed by The ACS Short Courses.  FREE EXHIBIT HALL ONLY PASS ($25 value), if
you register by August 9 - don't miss out.  Over 1,000 attendees and fully
packed exhibit hall (over 160 booths!) only at the World's Drug Discovery
Meeting Place - Visit:


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