Bioresearch Online Newsletter

Bioresearch Online newsletter at VERTICAL.NET
Thu Aug 19 01:04:26 EST 1999

Bioresearch Online Newsletter
Volume 2   Issue 43
Wednesday, August 18, 1999

Bioresearch Online Puts Out A Call For Papers

Hot, new results sometimes feel less hot and new after being put through a
grueling and often lengthy review process. Bioresearch Online is offering a
place for scientists to showcase preliminary results and receive feedback from
their peers before sending their findings off to a journal. Physicists have
been doing it for years---why not biologists?

For details, go to:

******** NATIONAL SPONSOR ********

The 9.99% fixed Bank One Platinum Business Card Visa. No annual fee and up
to $25,000 line of credit. Track expenses, simplify tax reporting, and
streamline your finances. Apply online by visiting:

******** Bioresearch Online’s Weekly Selection: ********

Toxicology and Risk Assessment: Principles, Methods, and Applications by A. Fan
and L. W. Chang
This unique resource introduces the fundamental principles and current concepts
of toxicology and risk assessment offering comprehensive discussions on
clinical testing.
Retail Price: $215.00 Our Price: $182.99! You Save: $32.01 (15%)
To read more and purchase this book, visit:

***** FEATURED ARTICLES selected by Laura DeFrancesco *****

1) New Approaches to Cloning: Part I
2) Taq Mutants Relieve Sequencing Woes
3) Bacterial Pili Structure Reveals Surprise


1) New Approaches to Cloning: Part I
In the beginning, there was pBR322. Following the seminal discovery that you
could cut and paste DNA into a plasmid and clone it, a cottage industry of
cloning vectors has emerged. There were the pUC vectors, the charon phages,
LIC’s, BAC’s, PACS and YAC’s. But every so often, a totally new idea emerges
from the cloning trenches, which can revolutionize the entire enterprise.

2) Taq Mutants Relieve Sequencing Woes
Sequencers take note---a group at Washington University School of Medicine’s
Department of Biochemistry and Molecular Biophysics have come up with new,
improved Taq polymerases. Using the structure of the enzyme at work as their
guide, they have created mutations that remove some annoying habits of this
workhorse enzyme.

3) Bacterial Pili Structure Reveals Surprise
Two papers published in the August 13 issue of Science present a never-before
seen picture of how bacterial pili are assembled, revealing in addition, novel
mechanisms termed donor strand exchange and donor strand complementation.
Scientists from the Washington University School of Medicine and Uppsala
Biomedical Center report separately the three-dimensional structure of
bacterial pili from two pathogenic strains. One set of data should aid in the
fight against bladder infection while a second set captures a key event in
kidney infection.

******** EDITOR'S CHOICE PRODUCTS ********

1) InsectSelect System
2) Microarray Slides
3) Automated Colony Picker


1) InsectSelect System
Invitrogen's InsectSelect System is a virus-free system that allows users to
create stable cell lines that continuously produce high-quality protein in any
insect line. InsectSelect takes less time and requires less effort than
baculovirus expression systems.

2) Microarray Slides
3D-Link Activated Slides from SurModics, provide reproducibility and
sensitivity for microarray applications.  The coating on these slides is a
three dimensional matrix that will covalently bind amine-terminated DNA.

3) Automated Colony Picker
Autogen's robotic system has the ability to automate colony or plaque picking.
It includes user-friendly decision making software and a high-resolution camera.


IBC Global Conferences - Upcoming events include: Chips to Hits 99, Phage
Display Technologies, SNPs, Biochip Technologies and Generic Drugs '99.  For
details on these conferences and other global events, visit us online at:


If you enjoy reading Bioresearch Online's Newsletter, please tell a
friend or colleague about it.  Anyone can sign up for a free
subscription on our Web site at


If your company wishes to sponsor this newsletter, please contact
Amy Vodraska at mailto:avodraska at to learn more.


If you wish to unsubscribe, please go to the following web page:

The Bioresearch Online Homepage:

(c) Copyright 1999 VerticalNet, Inc. All rights reserved. All
product names contained herein are the trademarks of their
respective holders.

More information about the Plant-ed mailing list