Transformation Stability

Peter M. pmcgarve at
Wed Nov 15 21:55:43 EST 1995

Its true that sometimes transgenes can lose activity over generations 
but not the rule. Many if not most lines of transgenic plants are very 
stable well over 3+ generations. The various comercial line approved for 
sale this year being the best examples. What is often seen and not 
understood is the phenomena of co-suppression in which adding more 
copies of a plant gene does not increase expression a great deal. The 
plant seems to down-regulate other copies. This is not seen in animal 
cells. There are other (probably RNA mediated) phenomena such as sense 
suppression and RNA mediated virus resistance that may have similar 

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