glyphosate: how does it kill?

Andy Phillips andy.phillips at
Wed Dec 4 10:15:18 EST 1996

paezzle at wrote:
> Does anyone out there know how the
> compound glyphosate (C3H8PNO5)
> kills?  Glyphosate is the active ingredient
> in the popular herbicide Roundup, manufactured
> by Monsanto.

Glyphosate inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSP 
synthase), an enzyme involved in the biosynthesis of the aromatic amino acids 
(Phe, Trp & Tyr). Glyphosate resistance in plants has been generated by 
introducing a glyphosate-resistant EPSP synthase from bacteria.

 Email  : andy.phillips at  : University of Bristol
 Home   : andy at     : IACR Long Ashton Research Station 
 Phone  : +44-1275-549257            : Long Ashton
 Fax    : +44-1275-394281            : Bristol, BS18 9AF, UK
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