glyphosate: how does it kill?

Andy Phillips andy.phillips at bbsrc.ac.uk
Wed Dec 4 10:15:18 EST 1996


paezzle at aol.com wrote:
> 
> Does anyone out there know how the
> compound glyphosate (C3H8PNO5)
> kills?  Glyphosate is the active ingredient
> in the popular herbicide Roundup, manufactured
> by Monsanto.

Glyphosate inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSP 
synthase), an enzyme involved in the biosynthesis of the aromatic amino acids 
(Phe, Trp & Tyr). Glyphosate resistance in plants has been generated by 
introducing a glyphosate-resistant EPSP synthase from bacteria.

Andy
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