Accessing Biological Diversity: Natural Product Drug Leads

[James W. Larkin]

Cambridge Healthtech Institute’s
Accessing Biological Diversity: Natural Product Drug Leads
November 20-21, 1997 
Hyatt Regency La Jolla, San Diego, California

Sources of Biological Diversity
Plant Cell Culture: A Novel Platform for Drug Discovery
        Dr. Christopher J. Pazoles, Phytera, Inc.
Assessing the Biomedical Future of Marine Microorganisms
        Dr. William Fenical, Scripps Institution of Oceanography
Discovery and Bioproduction of Novel Compounds from Marine and 
Halophilic Bacteria and Thermophilic Cyanobacteria
        Dr. Barbara J. Javor, CalBio Marine Technologies, Inc.
Cyanobacteria: Cosmopolitan Microorganisms That Rival Streptomycetes 
as Sources of Bioactive Secondary Metabolites
        Dr. Gregory M.L. Patterson, University of Hawaii
Transgenic Approaches to Identifying Compounds from Unculturable Fungi
        Dr. Thomas Adams, Texas A&M University and Millennium
        Pharmaceuticals, Inc.
Harvesting New Antimicrobial Agents From Marine Sources
        Dr. David Manyak, Oceanix Biosciences

Technology and Screening
Hay Baling vs. the Needle in the Haystack: A Comparison of Approaches 
to Biodiversity Prospecting from the Collector’s Perspective
        Dr. Douglas Daly, New York Botanical Garden
Natural Products: A Diverse Source of High-Quality Lead Compounds
        Dr. Ajay N. Jain, MetaXen LLC
Diverse Natural Product Libraries for Use in High-Throughput Screening
        Dr. Ursula Mocek, Panlabs, Inc.
Novel Approaches Towards Complete Diversity Profiles in Complex Matrices
        Dr. Reimar Bruening, Millennium Pharmaceuticals Inc.
SuperFluids™ Fractionation of Diverse Marine Microorganisms for Drug
Discovery
        Dr. Trevor Castor, Aphios Corporation

Combinatorial Products
Combinatorial Biology and Integrated Screening Technologies for 
Natural Products Lead Discovery
        Dr. David H. Sherman, ChromaXome Corporation
Combinatorial Optimization of Natural Product Drug Leads: The 
KombiNATURik Approach
        Dr. Kai Bindseil, Analyticon GmbH
Natural and Combinatorial Products
        Dr. Salvatore Forenza, Bristol-Myers Squibb Pharmaceutical 
        Research Institute
New Natural Product Templates for Combinatorial Chemistry and Drug 
Design
        Dr. John Nielsen, The Technical University of Denmark
Utilization of Microalgal Technology to Develop Novel Leads and Tools 
for Drug Discovery
        Dr. Hao Chen, Martek Biosciences Corporation
Making New Molecules the Natural Way Through Combinatorial Catalysis
        Dr. Douglas S. Clark, University of California, Berkeley and
        EnzyMed, Inc.

Applications
Discovery of Novel, Naturally Occurring, Anti-HIV Leads Using a 
LiveVirus/Host-Cell Infectivity Bioassay
        Dr. Michael R. Boyd, National Cancer Institute
Calanolides from Exotic Plant Protective Against HIV-1
        Dr. Michael Flavin, MediChem Research, Inc.
Discovery and Characterization of Novel Natural Products That May Be 
of Value in the Prevention of Human Cancer
        Dr. John Pezzuto, University of Illinois at Chicago
Potential for Treating CNS Disorder Using Small Peptide Molecules from 
the Venom of Predatory Marine Cone Snails (Conus)
        Dr. Tyler McCabe, Cognetix, Inc.

The level of diversity and biofunctionalism available in nature far 
exceeds what has been produced thus far using traditional medicinal 
chemistry or even combinatorial libraries. The resources of plants, 
marine organisms, microorganisms, and even terrestrial organisms have 
a great deal to offer drug discovery efforts, particularly when newer 
approaches are used to enhance the potential for identifying bioactive 
leads. Taking cues from plants or other remedies used historically as 
folk remedies or in other cultures, examining species that have barely 
been examined—such as extremophile organisms, most marine species, or 
organisms present in plants—and applying new technology for 
extraction, cell culture, or derivation of natural compounds are all 
strategies that are being employed and will be discussed. A session 
highlighting the use of combinatorial biology will also indicate how 
newer techniques can be applied for improving the potential of 
natural resources as a source of drug lead structures.

HOTEL INFORMATION
Hyatt Regency La Jolla at Aventine      T: 619-552-1234
3777 La Jolla Village Drive             F: 619-552-6066
San Diego, CA 92122                     
Cut-off Date: October 31, 1997          Room Rate: $135 Single/Double
Reservations made after the cut-off date will be accepted on a 
space-and-rate-availability basis. Available rooms are limited, 
so please book early.  Please identify yourself as a Cambridge
Healthtech Institute conference attendee to receive the reduced 
room rate.

TRAVEL INFORMATION
TRAVELWORLD                             T: 717-288-9311 or 800-828-6033
601 Market Street                       F: 717-288-4693
Kingston, PA 18704
Exclusive airline discounts are available on American Airlines as 
well as other specific airlines when tickets are purchased through 
Travelworld at least 14 days prior to the meeting date. Some 
restrictions apply.

CALL FOR POSTERS
Cambridge Healthtech Institute encourages attendees to gain further 
exposure by presenting their work in the poster sessions. Please fill 
out the registration form, with the poster title and primary author. 
To ensure inclusion in the conference binder, a one-page summary must 
be submitted by October 17, 1997.

CALL FOR EXHIBITORS
Space is available for companies interested in exhibiting products 
and services related to natural product drug leads. This meeting 
should attract up to several hundred senior researchers and managers 
representing a broad range of disciplines and perspectives. Please 
contact Jim MacNeil of Cambridge Healthtech Institute at 617-630-1341 
to obtain an exhibitor package or to inquire about offering a workshop 
during the meeting. Exhibit space is limited so call now to reserve a 
space at this premier event.

Each registration includes all conference sessions, posters and 
exhibits, one luncheon and reception, continental breakfasts, all 
refreshment breaks, and a copy of the document binder.

A group rate is available for three or more people from the same 
organization. Call for more details.

Handicapped Equal Access: In accordance with the ADA, Cambridge 
Healthtech Institute is pleased to arrange for special accommodations
for attendees with special needs. All requests for such assistance 
must be submitted in writing to CHI at least 30 days prior to the
start of the meeting.

Substitution/Cancellation Policy
In the event that you need to cancel a registration you may:
        Transfer your registration to a colleague within your 
        organization.
        Credit your registration to another Cambridge Healthtech 
        Institute program.
        Request a refund minus a $75 processing fee.
        Request a refund minus the cost ($150) of ordering a copy 
        of the document binder.
Cancellations will only be accepted up to one week prior to the 
conference.

Program and speakers are subject to change.

--------------------------Cut and Print Here------------------------

Yes! |__| Please register me for Natural Product Drug Leads  578E

Academic, Government, Hospital-Affiliated 
        |__| Early Registration (by September 5, 1997) $370
        |__| Advance Registration (by October 3, 1997) $395
        |__| On-site or Late Registration $445

Commercial 
        |__| Early Registration (by September 5, 1997) $695
        |__| Advance Registration (by October 3, 1997) $795
        |__| On-site or Late Registration $895

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