BRENDA enzyme database

Tom Schneider toms at fcs260c2.ncifcrf.gov
Mon Jul 22 19:43:08 EST 1991


Thanks to MSZ at XRAY.BMC.UU.SE (Michael Szardenings, Uppsala), I have got the
address of the editor of the BRENDA database,
SCHOMBURG at VENUS.GBF-BRAUNSCHWEIG.DBP.DE.  He is on vacation for a few weeks
(thanks to David Lincoln for this information), so I do not expect an answer
immediately.  However, Marc Roussel (mroussel at alchemy.chem.utoronto.ca) wanted
to know what was in the book, so I typed in the names of the contents.

The facts they include are nicely broken into sections for each enzyme:

1 NOMENCLATURE
  EC number
  systematic name
  recommended name
  synonymes
  cas reg no
2 REACTION AND SPECIFICITY
  catalysed reaction
  reaction type
  natural substrates
  substrate spectrum
  product spectrum
  inhibitor(s)
  cofactor(s)/prostethic group(s)
  metal compounds/salts
  turnover number
  specific activity
  Km-value
  pH-optimum
  pH-range
  temperature optimum
  temperature range
3 ENZYME STRUCTURE
  molecular weight
  subunits
  glycoprotein/lipoprotein
4 ISOLATION/PREPARATION
  source organism
  source tissue
  localisation in srouce
  purification
  crystalization
  cloned
  renatured
5 STABILITY
  pH
  temperature
  oxiddation
  organic solvent
  general stability information
  storage
6 CROSSREFERENCES TO STRUCTURE DATABANKS
  PIR/MIPS code
  Brookhaven code
7 LITERATURE REFERENCES

I may have mis-spelled or missed one, but there is the juicy list!  It sure is
comprehensive.  It seems to be organized by EC number, but in the electronic
database one should be able to do other things I imagine.  More later on when
Dr. Schomburg returns from vacation.

  Tom Schneider
  National Cancer Institute
  Laboratory of Mathematical Biology
  Frederick, Maryland  21702-1201
  toms at ncifcrf.gov



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