protein design using computational methods

Daniel Offutt mmvvmm at mixcom.COM
Thu May 9 11:59:46 EST 1991


I have found descriptions in the literature of various applications of
computational methods to protein *folding*.  But I have yet to discover
an article concerning the application of computational methods to protein
*design*.  Perhaps this should not be surprising, since a solution to the
folding problem appears to be a prerequisite to a solution to the general
protein design problem, and the folding problem appears to be computationally
intractable today.  Is this an accurate summary of the state of the art in
computational protein design?  If not, can anyone point out some articles on
computational protein design worth reading?  I would be interested even in
experiments with designing much-simplified "model" proteins.

Daniel Offutt



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