protein design using computational methods

[Maximum Slackness]

wrp at biochsn.acc.Virginia.EDU (William R. Pearson) writes:

>	I do not believe that there are any "well-known cases" of proteins
>of very similar sequence (>50% identity) folding into different
>conformations. I would be very interested in evidence to the contrary.

Consider ion channels such as the Axon Na+ Channel, the proton pore of
the V-Type ATPases, or lac permease.

Scott Howard
--

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