prot-prot binding sites

Wed Aug 5 12:35:00 EST 1992

If your four-subunit ion channel is anything like a five-subunit nicotinic
acetylcholine receptor, then perhaps the following text from a review
in TiPS August 1992 [Vol. 13] by Changeux et al. will be useful:

   ...and demonstrated that the recognition between subunits takes place
   primarily at the level of the extracellular N-terminal domain [8,9].
   Thus, despite their critical function in ion translocation, the
   hydrophobic uncharged segments seem to play little part in the
   specificity of interactions between subunits.

The references he gave are

8. Gu, Y., Camacho, P., Gardner, P. & Hall, Z.W. (1991) Neuron 6 879-887.
9. Verrall, S. & Hall, Z.W. (1992) Cell 68 23-31.

Good Luck!

< Ramin Nakisa,        She walks in beauty  Tel: 071 589-5111 x 6729       >
> Biophysics Section,  As the night of      FAX: 071 589-0191              <
< The Blackett Lab,    starry skies and     ramin at          >
> Imperial College,    cloudless climes...  biophys at         <
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