Transcription factor with 2 activation sites??? (fwd)

Keith Robison robison1 at husc10.harvard.edu
Sat Dec 19 12:06:47 EST 1992


ghj at mrc-lmb.cam.ac.uk (Jacobs "G.") writes:

>Just to add to the confusion, at least some of the DNA proteins with
>more than one DNA binding domain can select between them via alt.
>splicing. This could appear as activating at two different sites in
>some assays I guess (I'm not an experimentalist, but it does seem an
>obvious point...).
>I could give you some examples later (I'm not at my lab. at the 
>moment).

The Kafatos lab published a pair of papers on this in a recent Science
(about 1 month ago?)

>A point for myself is to distinguish between whether the protein binds
>the two promoters *AT THE SAME TIME* or whether it is able to bind
>the two promoters, but independently. Two very different things!

>Grant Jacobs
>MRC Laboratory of Molecular Biology
>Hillls Road 
>Cambridge CB3 9EU
>ENGLAND.


Keith Robison
Harvard University
Department of Cellular & Developmental Biology
Department of Genetics / HHMI

robison at biosun.harvard.edu 



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