*glycogen phosphorylase kinase

[Dan Jacobson]

Hmm,

Since my post on c-AMP dependent kinase seems to have gone for naught
I'll throw in these tidbits of information that a quick scan of
Swiss-Prot yielded.  The alpha subunit appears to be regulatory in 
function - who knows it may have a pseudosubstrate site which would
at least give my cA-kinase post some value :-).

Later,

Dan Jacobson

danj at welchgate.welch.jhu.edu



ID   KPBA$RABIT	    STANDARD;	   PRT;	 1237 AA.
AC   P18688;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-NOV-1990 (REL. 16, LAST ANNOTATION UPDATE)
DE   PHOSPHORYLASE KINASE ALPHA CHAIN, SKELETAL MUSCLE (EC 2.7.1.38).

ID	    KPBA$RABIT	   STANDARD;	  PRT;	1237 AA.
AC   P18688;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-NOV-1990 (REL. 16, LAST ANNOTATION UPDATE)
DE   PHOSPHORYLASE KINASE ALPHA CHAIN, SKELETAL MUSCLE (EC 2.7.1.38).
OS   ORYCTOLAGUS CUNICULUS (RABBIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; LAGOMORPHA.
RN   [1]
RP   SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.  RC   TISSUE=SKELETAL MUSCLE;
RC   MEDLINE=88203614;
RA   ZANDER N.F., MEYER H.E., HOFFMANN-POSORSKE E., CRABB J.W.,
RA   HEILMEYER L.M.G. JR., KILIMANN M.W.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 85:2929-2933(1988).
RN   [2]
RP   SEQUENCE OF 1016-1027.
RC   MEDLINE=75130982;
RA   COHEN P., WATSON D.C., DIXON G.H.;
RL   EUR. J. BIOCHEM. 51:79-92(1975).
RN   [3]  P   PHOSPHORYLATION.
	     90	01066
     MEYER H.E., MEYER G.F., DIRKS H., HEILMEYER L.M.G. JR.;   
RL   EUR. J. BIOCHEM. 188:367-376(1990). 
CC   -!- FUNCTION: PHOSPHORYLASE B KINASE CATALYZES THE PHOSPHORYLATION OF
CC       SERINE IN CERTAIN SUBSTRATES, INCLUDING TROPONIN I. THE ALPHA
CC       CHAIN MAY BIND CALMODULIN
CC   -!- CATALYTIC ACTIVITY: 4 ATP + 2 PHOSPHORYLASE B = 4 ADP +
CC       PHOSPHORYLASE A.
CC   -!- SUBUNIT: POLYMER OF 16 CHAINS, FOUR EACH OF ALPHA, BETA, GAMMA,
CC       AND DELTA. ALPHA AND BETA ARE REGULATORY CHAINS, GAMMA IS THE 
CC       CATALYTIC CHAIN, AND DELTA IS CALMODULIN.
CC   -!- PATHWAY: GLYCOGEN METABOLISM.
CC   -!- ENZYME REGULATION: BY PHOSPHORYLATION OF VARIOUS SERINE RESIDUES
CC       AND BY CALCIUM.