...looking for just the right peptide...

duca at binah.cc.brandeis.edu duca at binah.cc.brandeis.edu
Sun Nov 8 08:37:24 EST 1992


Hi there all you exquisitely architectured biological (and/or artificial)
        neural nets,

I'm trying to develop a theoretical model of ion channel formation within
a lipid bilayer.  I've settled on using certain "designer channels" made
by Lear and DeGrado at DuPont about 5-7 years ago, but unfortunately no
spectroscopy has been done on them and we don't have too clear an idea of
their structures.  Does anyone know of any serine and leucine rich alpha
helical proteins with good structural data available (X-ray or NMR)?
Seeing as initial parameter setting is so crucial in these models I want
to try to start with some known interatomic distances as first approximations.
Can anybody make a suggestion?  I'd really appreciate it.  Thanx in advance.

Karen Duca
Dept. of Biophysics
Brandeis U.
duca at binah.cc.brandeis.edu



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