[Steven Brenner]

genekdw at EMORYU1.CC.EMORY.EDU ("Keith D. Wilkinson") writes:
>In message 
>> From: pmr1716 at ggr.co.uk ("Peter Murray-Rust")
>> Subject: Effect of pressure on enzyme reactions
>> I'd be grateful for any information about whether high-pressure can affect 
>> (a)
>> the speed and/or (b) the equilibrium of an enzyme-catalysed reaction, and if
>> so, what pressures are required in practice to make a useful contribution.  
>> If
>> this is a well-researched field, I'd be very grateful for pointers to 
>> reviews.
>Try papers by Gregorio Weber at the University of Illinois.  His work centered 
>on the effectcs of pressure on subunit dissociation, but he may reference 
>effects on catalysis directly.  The equilibrium effect should be small but 
>calculable from first principles.

This message hints at the problem I think that you're going to run
into doing any "general" work with pressure effects on catalysis.  

I would expect that at the same pressures that would be likely to
affect reaction rates there will also be an effect on protein
structure.  This effect would, in turn, probably affect catalysis more
than the "first principles" equilibrium shift.

These are my assumptions, however, and I don't know whether this has
been demonstrated to be the case.

-- 
Steven E. Brenner               |  Department of Biochemistry      
seb1005 at mbfs.bio.cam.ac.uk      |  University of Cambridge         
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