Odd results with Proline in peptide synethsis

[Shaun D. Black]

Dear All,
     We've recently gotten some seemingly bizarre results from synthesis of 
a peptide containing a number of prolyl residues.  Specifically, we've 
found that the chain spontaneously cleaves during synthesis, but the 
cleavage is not at a proline  :-?  .  Would some of you who might have seen 
effects somewhat like this e-mail us.  We'd appreciate some discussion.  
Thanks a bunch.  Cheers,  Shaun
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  = Shaun D. Black, PhD     | Internet:  shaun%jason.decnet at relay.the.net = 
  = Dept. of Biochemistry   | University of Texas Health Center, at Tyler = 
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