Summary -- Membrane protein crystallization technique

Richard P. Muller rpm at bach.wag.caltech.edu
Tue Nov 16 18:20:42 EST 1993


Schafmeister et al. (Science 262:734 (1993)) recently published a
method for solubilizing membrane proteins by complexing them with
alpha helices with one flat hydrophobic side to interact with the
transmembrane protein.

Two weeks ago I posted a message to bionet.molbio.proteins asking for
comments on the procedure, and whether such a method was general
enough so that crystal structures of a large number of membrane
proteins would soon be available. What follows is a summary of the
responses I received. Thanks to everyone who took the time.

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[This is from one of the authors of the paper...]



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