QUESTIONS: alpha-helix "signals" in proteins

Ken Prehoda kenp at nmrfam.wisc.edu
Tue Jul 5 17:54:58 EST 1994


In article <2vbu05$det at lyra.csx.cam.ac.uk>
Ben Davis, bjd12 at cus.cam.ac.uk writes:
>	I think that more proteins need to be characterised under denaturing
>conditions before the question of structure in unfolded proteins can be
>answered properly. Certainly in the cases where unfolded proteins have
been
>characterised (434 repressor, FK506 BP) structures have been found. They
>tend to be marginal, rather than persistent, but they do seem to be
formed.
>This kind of implies that local interactions can form, and so presumably
>would form early in a folding reaction. 

You make a valid point, however, I would suggest that the only
denatured states that we see in the literature are those that have
some type of structure (however little it may be).  For proteins that
do have fully unfolded denatured states, there is little incentive
to publish.  

>______________________________________________________________________
_______
>
>Ben Davis,
>MRC Protein Function and Design,
>Cambridge, UK
>______________________________________________________________________
_______
>
>"They can make me do it, but they can't make me do it with dignity."

-Ken Prehoda
kenp at nmrfam.wisc.edu



More information about the Proteins mailing list