QUESTIONS: alpha-helix "signals" in proteins
ram at mbisgi.umd.edu
Thu Jul 14 11:08:54 EST 1994
Toshiya Endo (d43162a at nucc.cc.nagoya-u.ac.jp) wrote:
>The tendency of proteins to fold fast to native conformations may not be
>sequence independent. Nature may well have selected proteins that can
>fold fast, since polypeptides that remain unfolded in the cells are degraded
>by specificf proteases.
This is not a flame, but I think this is stating the obvious. I
really don't see what Karplus, et al., have done in their paper that
And finally, Karplus in the Nature paper proposes something like the
framework model, but in protein science a few months ago he pushes the
diffusion-collision model (which I do like a lot---I think it's at
least one mechanism by which proteins fold), both which I find are
contradictory to each other.
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