Length of peptide and Immunological Resistance

Jeffrey L Nauss naussjl at ucunix.san.uc.edu
Wed Mar 2 09:23:13 EST 1994

In article <genecutl-010394202653 at kos2mac16.berkeley.edu> genecutl at mendel.berkeley.edu (gc) writes:
>I think MHC receptors present peptides of around ten to twelve
>amino acids to T cells.  A peptide smaller than this can't be
>presented and won't be very immunogenic.

Class I MHC's present peptides of 8-9 amino acids in length.  Class II
are variable with lengths in the neighborhood of 12-16 residues.

Jeff Nauss				Texas A&M Class of '77
Department of Chemistry			Gig 'em, Aggies!
University of Cincinnati

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