Xenobiotic Nitro-reduction Enzymes

Mary Elyse Lucero malucero at nmsu.edu
Fri Mar 4 12:55:30 EST 1994


Does anyone out there know of any reviews or other references describing
enzymes or classes of enzymes which are responsible for reduction of
nitro- groups on nitroaromatics or other xenobiotic compounds?  In vivo,
these nitro groups are often converted to amino-groups.  This has been
well documented through radiolabeled metabolite studies.  However, these
studies rarely examine the enzymes involved.  

I have read up on nitrate and nitrite reductase enzymes, but so far
have found nothing to suggest that these enzymes act on anything other
than free nitrate/nitrite.  

I would very much appreciate any references you can suggest. 

Thanks!




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