ewright at FOX.NSTN.NS.CA
Sun Mar 6 21:34:11 EST 1994
The following statement appeared in Nature:
"There are now many examples, in both functionally similar and dissimilar
proteins, where the sequence similarity is statistically insignificant (less
than 20%) and yet the same topology is observed." (M. Thornton, T.P. Flores,
D.T. Jones, M.B. Swindells, Nature, 354, 105, (1991) - p. 106)
If this situation is common, then it seems that notwithstanding functional
similarity/dissimilarity, topological similarity is dependent on a meta-
sequential order, not readily apparent at the level of independently
displayed sequences. Presumably, this meta-sequential order is governed by
one of the following possibilities:
1. There is a distinct set of sequences (the basis of which is unknown)
responsible for a specific topology.
2. The set of sequences responsible for a specific topology are actually
manifesting conserved positions (albeit non-conserved residues) of a
single (unknown) meta-sequence.
Is anyone aware of any research with respect to the second possibility?
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