cAMP stability
mellott james bs bioc
jmello1 at umbc.edu
Wed Mar 9 13:01:48 EST 1994
In my biochemistry class , we're talking about glycolysis , TCA , etc.,
and one of the topics is the regulation of glycogen through a cAMP pathway . It
is my understanding that a high concentration of cAMP is needed for the
continuous activation of Protein kinase , and to inactivate the kinase , the
concentration of cAMP is lowered through the activity of a phosphodiesterase .
I recall hearing that caffeine stabilizes the concentration of cAMP in such a
pathway , and I was wondering , since caffeine and adenine have similar
structures , if caffeine acts as a competitive inhibitor with cAMP for the
phosphodiesterase .
Thanks in advance for any comments and/or references you can give me .
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