Acylation of Ser

Ding Ming ming at
Fri Mar 18 16:47:23 EST 1994

In article <2mcjt5$7nu at>, JAB5 at VAX.YORK.AC.UK wrote:

> Dear colleagues,
> I remember something about N-terminal Serines which become acylated
> (possibly an alcohol or aldehyde dehydrogenase example?) but can't
> recall much else.
> What does this really mean? Where does the acyl group come from?
> Is there a known physiological role/mechanism for this?
> Any help or pointers to the lit. would be much appreciated.

Please take a look at D. Wellner et al., Sequencing of peptides and
proteins with blocked N-terminal amino acids: N-acetylserine or
N-acetylthreonine. PNAS 87, 1947(1990).

Good luck!
Ding Ming
University of Wisconsin-Madison
Telephone: (608)265-3544     Fax: (608)262-7420

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