Equivalent amino acids for similarity searches

Roberto Albinoni dy684 at cleveland.Freenet.Edu
Tue Mar 22 04:57:13 EST 1994


i am comparing the dna-derived amino acids sequences of two proteins in
order to determine which residues may be most important to enzymatic
function. 

i wonder if someone to point me to appropriate references on which amino
acids can be considered most similar based on their chemistry and function,
and also how one can 'score' the similarity of two proteins based not only
on identical residues, but also on amino acids which belong to the same
chemical families.



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