free energies.

Manuel Marolt Rodriguez man at leland.Stanford.EDU
Wed Nov 30 13:29:18 EST 1994


In article <Pine.SUN.3.90.941123154800.15312A-100000 at snfma1.if.usp.br>,
Rafael Iosef Najmanovich Szeinfeld {S <szeinfel at SNFMA1.IF.USP.BR> wrote:

>	I would like some references which calculate or measure the free 
>energy change (DG) in transfering an alanine or glycine from water to a 
>nonpolar solvent and the free energy change for the transfer of a valine 
>from the same nonpolar solvent to water, all this to have an idea (quite 
>approximated) about the ratio between the DG of a hydrogen bond and the 
>DG of a hidrophobic interaction.
>	I know that the data I'm asking for is not enough to adress my 
>problem but it may be seen as a first aproximation.

As a starting point, I would suggest looking at
	Eriksson et al., Science 255,178-183 (1992).
and references therein (if you haven't already).

Good luck,

Manuel Rodriguez
man at leland.stanford.edu
Department of Molecular Pharmacology
Stanford University School of Medicine
Stanford, CA  94306





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