Stability of Okadaic Acid & Calyculin A

Jim Cheetham cheethj at ROCKVAX.ROCKEFELLER.EDU
Tue Jan 10 10:41:55 EST 1995


>Does anybody know how stable the protein phosphatase inhibitors okadaic
>acid, calyculin A and tautomycin are, once made up in solution. How long do
>they retain their inhibitory activity, how to store them, etc?
>
>Many thank's in advance
>
>
>Rory Morty
>morty at biochem.unp.ac.za

While we have not measured this parameter extensively, I would set an
upper limit for stabilility of these phosphatase inhibitors in aqueous
solution of 24 hours.  It is probably better to use these compounds as
soon as possible after making up the solution.

Jim

James J. Cheetham, Ph.D.
Laboratory of Molecular and Cellular Neuroscience
The Rockefeller University
1230 York Ave
New York, NY 10021
USA
cheethj at Rockvax.Rockefeller.EDU





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