peptide helicity at different pH values

Manpreet S Wadhwa mwadhwa at magnus.acs.ohio-state.edu
Thu Jan 12 22:40:59 EST 1995


hi,

i remember from my proteins class that the propensity of a peptide or protein
to form a helical secondary structure can be calculated by a method of
averaging out empirical values assigned to amino acid residues (work done by
chou and fasman?). i have recently become interested at computing the
helicity of short (20-40 mer) peptides, however at different pH values.
i think the values assigned to acidic and basic residuess would vary with pH,
i'm not sure about neutral residues. does anyone know of any references
which deal with this question? also, does this kind of computation of
helicity give fairly reliable estimates?

thanks,
/manpreet.



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