Ionic effects on solubility at pI
bl275 at cleveland.Freenet.Edu
Tue Jan 17 19:28:34 EST 1995
ive had some difficulty finding papers which discuss the effects of
ionic strength on protein solubility at the isoelectric point.
one review article suggested that a protein is minimally soluble at low
ionic strength at its pI. a colleague suggested that the low solubility at
the pI can be further decreased by salting out.
- is the isolectric point dependent on ionic strength?
- is it possible to generalize about whether salting out agents can further
decrease the solubility of a protein at its isoelectric point?
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