Ionic effects on solubility at pI

Dan Diaz bl275 at cleveland.Freenet.Edu
Tue Jan 17 19:28:34 EST 1995

ive had some difficulty finding papers which discuss the effects of
ionic strength on protein solubility at the isoelectric point.

one review article suggested that a protein is minimally soluble at low
ionic strength at its pI.  a colleague suggested that the low solubility at
the pI can be further decreased by salting out.

- is the isolectric point dependent on ionic strength?
- is it possible to generalize about whether salting out agents can further
decrease the solubility of a protein at its isoelectric point?

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