URATE OXIDASE (URICASE)

THOMAS L SELBY tselby at magnus.acs.ohio-state.edu
Tue Jan 31 12:10:30 EST 1995




Hi

	I am looking for some recent references that deal with the mechanism of 
action of Uricase for a paper I am doing for an enzyme mechanisms course at 
OSU.  I have read through many articles describing the sequence homology for 
the various plants and bacteria, and the closest I have come to a mechanistic 
study  is from a study by Ito M. where he described a single mutation and gave 
the resulting Km values.

	If possible I would like to find some studies dealing with substrate analogs, 
stereochemical aspects, and overall mechanism of action for the enzyme.  Many 
of the references I have located are from the 1960s and I know there must be 
some more recent work out there somewhere.

Thanks in advance.


Thomas L Selby
tselby at magnus.acs.ohio-state.edu  



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